Tianeptine Sodium CAS: 30123-17-2 5-dioxide Stablon S-Dioxide Sodium Salt

ISTICMAALA

Tianeptine sodium cusbo waa antidepressant tricyclic, iyo habka ka hortagga niyad-jabka waa ka duwan yahay tricyclic antidepressants.Waxay kordhin kartaa dib-u-qaadista 5-HT ee booska synaptika, waxaana laga yaabaa inay saameyn ku yeelato hagaajinta habka 5-HT neurons.Ma jiro wax xidhiidh ah oo u dhexeeya choline ama adrenaline reseptors.Waxtarka ka hortagga niyad-jabka waxay la mid tahay tricyclic, laakiin dulqaadku wuu ka fiican yahay tricyclic.Tijaabooyinka xayawaanka, waxay kordhin kartaa dhaqdhaqaaqa iskood ah ee unugyada pyramidal ee hippocampus waxayna kordhisaa soo kabsashadooda ka dib joojinta shaqada.Buuga kiimikaad waxa uu kordhiyey dib u nuugista serotonin ee neurons-ka kortex maskaxda iyo hippocampus.Nuugista sodium tineptine ee habka dheef-shiidka waa mid degdeg ah oo dhammaystiran.Qaybinta degdega ah, PPB ilaa 94%.Waxaa si buuxda u dheefshiiday beerka by β-oxidation iyo N-demethylation, iyo nadiifinta terminal T1 / 2 ahaa gaaban 2.5h.Qadar aad u yar oo daawada ah (8%) ayaa laga soo saaray kelyaha, gaar ahaan dheef-shiid kiimikaad ee kaadida.Bukaannada qaba kelyo-yaraanta ayaa la fasaxay T1/2 muddo 1 saac ah oo dheer.